Villa Serena is the original historic site of the DePelchin Faith Home completed in 1913. It was designed by the noted St. Louis architectural firm of Mauran and Russell.

The building served as an orphanage until 1938. It was chartered in 1893 and named as a memorial to Kezia Payne DePelchin, a pioneer in the field of social work in Houston.

The architectural design of the roof soffit and arched windows are dominant elements of this historic building. The home was converted to fifteen distinctive historic condominiums in 2002.

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